I've been to both previous conferences and can heartily recommend the experience. Here's a panoramic photo of the main room that I took at this year's edition. You can see more on my flickr account.
At the time of writing, the speakers for the 2013 edition have yet to be announced but at both previous events the speakers have been of a consistently high quality. There were several "big names" such as Steve Novella, Jim Al-Khalili and Eugenie Scott in 2011, and Edzard Ernst, Steve Jones and Richard Wiseman in 2012. Even those speakers I hadn't heard of before the event turned out to be fascinating and entertaining. I can't wait to see who they announce for this year!
A new addition for this year is the provision of child care facilities which means that parents of children up to the age of twelve will be able to attend and leave their kids in a safe environment.
I hope to see you there!
Addendum: The first of the speakers have been announced and it's looking good!